A frozen embryo transfer (FET) is the transfer of an embryo which has been formerly frozen, and subsequently thawed, in to the womb. Traditionally, IVF has involved ovarian stimulation accompanied by egg access and fertilization of harvested eggs, then a new embryo transfer (ET) of the embryo into the uterus inside five days of the egg retrieval procedure, also referred to as IVF-ET. With the introduction of sophisticated embryo freezing and thawing techniques achieving extremely high embryo success prices, conventional IVF-ET (using fresh embryos) has grown to be more uncommon, providing way to the more commonly practiced FET.
Iced embryo transfer (FET) periods are becoming essential components of the IVF process and thus has to be carried out with excellent treatment to accomplish an effective outcome. Several elements form an effective FET period. An effective evaluation in the uterine cavity to eliminate the existence of an intracavitary lesion (like a polyp or fibroid that may hinder implantation) must be carried out prior to the FET cycle. The vast majority of FET cycles are medicated FET cycles, where estrogen supplementation is initially administered in order to formulate the uterine lining (called the endometrial echo complicated below sonography evaluation), until an optimal density from the lining is accomplished. This stage in the Dr. Eliran Mor Reviews is crucial and the kind of and method of estrogen supplementation utilized (oral oestrogen pills, vaginal oestrogen suppositories, injectable estrogen, subcutaneous oestrogen), the dosage of estrogen, and the length of time of oestrogen supplements are essential and should be customized and modified to every patient according to several aspects, so that a responsive uterine lining is achieved. The second stage of the medicated FET cycle entails progesterone supplements, exposed to keep the coating, once an optimal uterine coating has been accomplished. In medicated FET cycles, progesterone is introduced as the estrogen supplementation is adjusted and continued. As with the case of estrogen supplements, the type, dose, and path of progesterone supplements, is critical. Generally, progesterone is launched by means of intramuscular daily injections 5 days prior to the embryo move of a iced-thawed embryo. Progesterone can also be administered as vaginal suppositories or a mixture of intramuscular injections and vaginal suppositories. The frozen embryo move should timed accurately to the initiation of progesterone supplementation in order for that FET to be successful. Estrogen and progesterone supplements is usually continued after the embryo move and thru 10 days of gestation.
An unmedicated FET cycle, also known as an all natural cycle FET, is usually carried out without any estrogen or progesterone supplements. Rather, the estrogen made by a normally expanding ovarian follicle, followed by progesterone created after spontaneous ovulation of this follicle; secure the implantation of a iced-thawed embryo, if the FET is timed properly for the duration of ovulation. Natural cycle FETs do not let for versatility within the the right time of the FET and are only appropriate for patients with typical menstrual cycles, in which ovulation is easy to monitor and is also foreseeable.
In certain clinical scenarios, a activated FET period is conducted. Within a activated FET cycle the patient administers gonadotropin hormone injections (or mouth ovulation induction medications) to cause the expansion of the follicle or follicles. The development of follicles leads for the endogenous production of estrogen which then leads towards the thickening of the uterine coating. Once follicles achieve a mature dimension, they may be cqollj to ovulate, leading to producing endogenous progesterone, which then units the phase for that embryo move of a frozen-thawed embryo. Stimulated FET periods may be used in patients that do not ovulate normally or in situations where conventional medicated FET cycles have failed.